Selective Detection of Peptide-Oligonucleotide Heteroconjugates Utilizing Capillary HPLC-ICPMS
نویسندگان
چکیده
منابع مشابه
Characterization of peptide-oligonucleotide heteroconjugates by mass spectrometry.
Two peptide-oligothymidylic acids, prepared by joining an 11 residue synthetic peptide containing one internal carboxyl group (Asp side chain) to amino-linker-5'pdT6 and amino-linker-5'pdT10 oligonucleotides, were analyzed by matrix-assisted laser desorption/ionization (MALDI) on a linear time-of-flight mass spectrometer and by electrospray ionization (ESI) on a triple-quadrupole system. These ...
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ژورنال
عنوان ژورنال: Journal of The American Society for Mass Spectrometry
سال: 2012
ISSN: 1044-0305,1879-1123
DOI: 10.1007/s13361-012-0366-2